Assay Detail
Binding
CHEMBL2327952
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Positive allosteric modulation of GABAA alpha1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit alpha-1 (CHEMBL1962) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ion channels as therapeutic targets: a drug discovery perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.43 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363211 | — | — | 1 | 9.10 |
| CHEMBL45198 | — | — | 1 | 8.89 |
| CHEMBL52030 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363211 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL45198 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL52030 | — | Ki | = | 49.0 | nM | 7.31 |