Assay Detail
Functional
CHEMBL2328233
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Antiviral activity against Machupo virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mammarenavirus machupoense |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.80 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2314859 | — | — | 1 | 8.51 |
| CHEMBL2322820 | — | — | 1 | 7.92 |
| CHEMBL2322822 | — | — | 1 | 7.40 |
| CHEMBL2322826 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2314859 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2322820 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2322822 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2322826 | — | EC50 | = | 45.0 | nM | 7.35 |