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Compound Detail

CHEMBL2322822

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COc1ccc(-n2cnc3cc(N(Cc4ccc(C(C)C)cc4)S(=O)(=O)c4ccc(C)cc4)ccc32)cc1

Basic Information

ChEMBL ID CHEMBL2322822
Phase Preclinical
Structure Type MOL
InChI Key DUNDKBOYYKJVAY-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

525.7
MW (Da)
6.86
ALogP
5
HBA
0
HBD
64.4
PSA (Ų)
0.22
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H31N3O3S
MW 525.67
Aromatic Rings 5
Heavy Atoms 38
NP-Likeness -1.54

Activity Summary

EC50 4 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Junin virus
CHEMBL4523072
EC50 7.8 7.8 16.0 1
Machupo mammarenavirus
CHEMBL4888477
EC50 7.4 7.4 40.0 1
Lassa virus
CHEMBL615051
EC50 6.96 6.96 110.0 1
NON-PROTEIN TARGET
CHEMBL3879801
EC50 6.29 6.29 510.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23265895 10.1016/j.bmcl.2012.11.095 NON-PROTEIN TARGET 2
23265895 10.1016/j.bmcl.2012.11.095 Junin virus 1
23265895 10.1016/j.bmcl.2012.11.095 Machupo mammarenavirus 1
23265895 10.1016/j.bmcl.2012.11.095 Lassa virus 1

Data from ChEMBL 36 via Core Engine