Assay Detail
Binding
CHEMBL2328496
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Inhibition of Beta-lactamase SHV-1 K234R protein mutant in Escherichia coli DH10B by Henri-Michaelis-Menten steady state equation analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.56 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326847 | — | — | 1 | 8.62 |
| CHEMBL1277225 | — | — | 1 | 7.92 |
| CHEMBL2326848 | — | — | 1 | 7.87 |
| CHEMBL2326846 | — | — | 1 | 7.32 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 6.05 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 5.34 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 5.11 |
| CHEMBL320049 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326847 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1277225 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2326848 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL2326846 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL404 | TAZOBACTAM | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL403 | SULBACTAM | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL777 | CLAVULANIC ACID | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL320049 | — | Ki | = | 61000.0 | nM | 4.21 |