Assay Detail
Functional
CHEMBL2328541
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Inhibition of TNF-alpha production in LPS-stimulated human PBMC preincubated for 1 hr before LPS challenge measured after 28 to 20 hrs by ELISA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.53 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324719 | — | — | 1 | 8.00 |
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 7.89 |
| CHEMBL2324726 | — | — | 1 | 7.26 |
| CHEMBL2324705 | — | — | 1 | 7.10 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 7.00 |
| CHEMBL2324715 | — | — | 1 | 7.00 |
| CHEMBL2324709 | — | — | 1 | 5.92 |
| CHEMBL2324718 | — | — | 1 | 5.54 |
| CHEMBL2324725 | — | — | 1 | 5.46 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | 4.11 |
| CHEMBL2324711 | — | — | 1 | - |
| CHEMBL2324708 | — | — | 1 | - |
| CHEMBL2324707 | — | — | 1 | - |
| CHEMBL2324706 | — | — | 1 | - |
| CHEMBL2324712 | — | — | 1 | - |
| CHEMBL2324704 | — | — | 1 | - |
| CHEMBL2324703 | — | — | 1 | - |
| CHEMBL2324702 | — | — | 1 | - |
| CHEMBL2324710 | — | — | 1 | - |
| CHEMBL2324714 | — | — | 1 | - |
| CHEMBL2324724 | — | — | 1 | - |
| CHEMBL2324723 | — | — | 1 | - |
| CHEMBL2324722 | — | — | 1 | - |
| CHEMBL2324721 | — | — | 1 | - |
| CHEMBL2324720 | — | — | 1 | - |
| CHEMBL2324716 | — | — | 1 | - |
| CHEMBL2324717 | — | — | 1 | - |
| CHEMBL2324713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324719 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2324726 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2324705 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2324715 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2324709 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2324718 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2324725 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL2324711 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324708 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324707 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324706 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324712 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324704 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324703 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324702 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324710 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324714 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2324723 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2324722 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2324721 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2324720 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2324716 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324717 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2324713 | — | IC50 | > | 1000.0 | nM | - |