Compound Detail
CHEMBL2324714
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Basic Information
| ChEMBL ID | CHEMBL2324714 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XMPJICVFSDYOEG-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
274.2
MW (Da)
-0.21
ALogP
5
HBA
2
HBD
103.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon/DNA damage-binding protein 1 CHEMBL4630734 | IC50 | 7.54 | 7.3 | 28.9 | 2 |
| Protein cereblon CHEMBL3763008 | IC50 | 6.2 | 6.2 | 630.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon/DNA damage-binding protein 1 | IC50 | = | 28.9 | nM | 7.54 | CRBN-DDB1 ligand-displacement AlphaScreen Assay: A thalidomide competition Alpha... | - |
| Protein cereblon/DNA damage-binding protein 1 | IC50 | = | 87.0 | nM | 7.06 | CRBN-DDB1 ligand-displacement AlphaScreen Assay: A thalidomide competition Alpha... | - |
| Protein cereblon | IC50 | = | 630.0 | nM | 6.2 | Displacement of fluorescent tracer from NanoLuc-tagged CRBN (unknown origin) by ... | 36970148 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32832021 | 10.1021/acsmedchemlett.0c00194 | No relevant target | 2 |
| 36970148 | 10.1039/d2md00347c | Protein cereblon/GSPT1 | 2 |
| 36191408 | 10.1016/j.ejmech.2022.114792 | Unchecked | 2 |
| 36191408 | 10.1016/j.ejmech.2022.114792 | Receptor-type tyrosine-protein kinase FLT3 | 2 |
| 23168019 | 10.1016/j.bmcl.2012.10.071 | NON-PROTEIN TARGET | 1 |
| 23168019 | 10.1016/j.bmcl.2012.10.071 | T-cell | 1 |
| 23168019 | 10.1016/j.bmcl.2012.10.071 | PBMC | 1 |
| 32832021 | 10.1021/acsmedchemlett.0c00194 | Albumin | 1 |
| 32832021 | 10.1021/acsmedchemlett.0c00194 | von Hippel-Lindau disease tumor suppressor/Androgen receptor | 1 |
| 36970148 | 10.1039/d2md00347c | Protein cereblon | 1 |
| 36970148 | 10.1039/d2md00347c | Cereblon/Ikaros | 1 |
Data from ChEMBL 36 via Core Engine