Assay Detail
Binding
CHEMBL5256274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescent tracer from NanoLuc-tagged CRBN (unknown origin) by NanoBRET assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.17 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324726 | — | — | 1 | 6.63 |
| CHEMBL2324704 | — | — | 1 | 6.47 |
| CHEMBL182442 | — | — | 1 | 6.42 |
| CHEMBL40206 | — | — | 1 | 6.42 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 6.41 |
| CHEMBL43855 | — | — | 1 | 6.25 |
| CHEMBL304572 | — | — | 1 | 6.22 |
| CHEMBL2324714 | — | — | 1 | 6.20 |
| CHEMBL297116 | — | — | 1 | 6.18 |
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 6.13 |
| CHEMBL2324703 | — | — | 1 | 5.94 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | 5.83 |
| CHEMBL2324702 | — | — | 1 | 5.70 |
| CHEMBL296118 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324726 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL2324704 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL182442 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL40206 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL43855 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL304572 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL2324714 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL297116 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL2324703 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL2324702 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL296118 | — | IC50 | = | 2900.0 | nM | 5.54 |