Assay Detail
Binding
CHEMBL2328820
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Inhibition of PI3Kbeta (unknown origin)
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.94 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322340 | — | — | 1 | 9.40 |
| CHEMBL2322331 | — | — | 1 | 9.40 |
| CHEMBL2322338 | — | — | 1 | 9.20 |
| CHEMBL2089106 | — | — | 1 | 9.20 |
| CHEMBL2322332 | — | — | 1 | 9.00 |
| CHEMBL2322344 | — | — | 1 | 8.90 |
| CHEMBL2322335 | — | — | 1 | 8.60 |
| CHEMBL2322337 | — | — | 1 | 8.60 |
| CHEMBL2322341 | — | — | 1 | 8.60 |
| CHEMBL2322333 | — | — | 1 | 8.40 |
| CHEMBL2322349 | — | — | 1 | 8.30 |
| CHEMBL2322336 | — | — | 1 | 8.30 |
| CHEMBL2322342 | — | — | 1 | 8.20 |
| CHEMBL2322345 | — | — | 1 | 8.10 |
| CHEMBL2322339 | — | — | 1 | 7.90 |
| CHEMBL2322356 | — | — | 1 | 7.70 |
| CHEMBL2322350 | — | — | 1 | 7.60 |
| CHEMBL2322353 | — | — | 1 | 7.40 |
| CHEMBL2322352 | — | — | 1 | 7.40 |
| CHEMBL3145359 | — | — | 1 | 7.20 |
| CHEMBL2322347 | — | — | 1 | 6.50 |
| CHEMBL2322334 | — | — | 1 | 6.50 |
| CHEMBL2322348 | — | — | 1 | 6.10 |
| CHEMBL2322346 | — | — | 1 | 6.00 |
| CHEMBL2322354 | — | — | 1 | 5.90 |
| CHEMBL2321882 | — | — | 1 | - |
| CHEMBL2322351 | — | — | 1 | - |
| CHEMBL2322355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322340 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL2322331 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL2322338 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL2089106 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL2322332 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2322344 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL2322335 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL2322337 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL2322341 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL2322333 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL2322349 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL2322336 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL2322342 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL2322345 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL2322339 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL2322356 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL2322350 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL2322353 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL2322352 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3145359 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL2322347 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL2322334 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL2322348 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL2322346 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2322354 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2321882 | — | IC50 | > | 3162.28 | nM | - |
| CHEMBL2322351 | — | IC50 | > | 1258.93 | nM | - |
| CHEMBL2322355 | — | IC50 | > | 1258.93 | nM | - |