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Assay Detail

CHEMBL2328856

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human GXF251L cells after 72 hrs by SRB assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.
Baechler SA, Fehr M, Habermeyer M, Hofmann A, Merz KH, Fiebig HH, Marko D, Eisenbrand G.
Bioorg Med Chem (2013) 21 : 814 -823
PubMed 23266176 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.09 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2323155 1 6.05
CHEMBL2323164 1 5.80
CHEMBL2323165 1 5.72
CHEMBL2323151 1 5.60
CHEMBL253553 LYCOBETAINE 1 5.50
CHEMBL2323149 1 5.46
CHEMBL2323156 1 5.40
CHEMBL2323160 1 5.27
CHEMBL2323153 1 5.11
CHEMBL2323158 1 5.08
CHEMBL511443 TRISPHAERIDINE 1 4.92
CHEMBL2323154 1 4.92
CHEMBL2323163 1 4.76
CHEMBL2323162 1 4.73
CHEMBL2323150 1 4.62
CHEMBL2323161 1 4.58
CHEMBL2323157 1 4.39
CHEMBL2323152 1 4.39
CHEMBL2323148 1 4.38
CHEMBL2323159 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2323155 IC50 = 900.0 nM 6.05
CHEMBL2323164 IC50 = 1600.0 nM 5.80
CHEMBL2323165 IC50 = 1900.0 nM 5.72
CHEMBL2323151 IC50 = 2500.0 nM 5.60
CHEMBL253553 LYCOBETAINE IC50 = 3200.0 nM 5.50
CHEMBL2323149 IC50 = 3500.0 nM 5.46
CHEMBL2323156 IC50 = 4000.0 nM 5.40
CHEMBL2323160 IC50 = 5400.0 nM 5.27
CHEMBL2323153 IC50 = 7800.0 nM 5.11
CHEMBL2323158 IC50 = 8400.0 nM 5.08
CHEMBL511443 TRISPHAERIDINE IC50 = 12000.0 nM 4.92
CHEMBL2323154 IC50 = 12100.0 nM 4.92
CHEMBL2323163 IC50 = 17300.0 nM 4.76
CHEMBL2323162 IC50 = 18800.0 nM 4.73
CHEMBL2323150 IC50 = 23700.0 nM 4.62
CHEMBL2323161 IC50 = 26000.0 nM 4.58
CHEMBL2323157 IC50 = 40600.0 nM 4.39
CHEMBL2323152 IC50 = 41100.0 nM 4.39
CHEMBL2323148 IC50 = 41200.0 nM 4.38
CHEMBL2323159 IC50 > 50000.0 nM -