Assay Detail
Functional
CHEMBL2328868
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Antiproliferative activity against human HCT116 cells assessed as inhibition cell proliferation after 48 hrs by Sulforhodamine B assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.98 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464670 | — | — | 1 | 6.31 |
| CHEMBL517462 | — | — | 1 | 6.19 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464670 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL517462 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3560.0 | nM | 5.45 |