Assay Detail
Functional
CHEMBL2329429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type Hepatitis B virus infected in human HuH7 cells
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 4 | - | - |
| EC50 | 4 | 7.21 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | 4.0 | 2 | 8.10 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 2 | 7.25 |
| CHEMBL2326505 | — | — | 2 | 7.21 |
| CHEMBL2326504 | — | — | 2 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2326505 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2326504 | — | EC50 | = | 548.0 | nM | 6.26 |
| CHEMBL5314362 | ENTECAVIR | EC90 | = | 0.033 | uM | - |
| CHEMBL141 | LAMIVUDINE | EC90 | = | 0.142 | uM | - |
| CHEMBL2326505 | — | EC90 | = | 0.46 | uM | - |
| CHEMBL2326504 | — | EC90 | = | 6.0 | uM | - |