Assay Detail
Binding
CHEMBL2329438
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Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.09 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572366 | — | — | 1 | 7.10 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 5.51 |
| CHEMBL2326516 | — | — | 1 | 5.22 |
| CHEMBL2326521 | — | — | 1 | 5.17 |
| CHEMBL2326511 | — | — | 1 | 5.17 |
| CHEMBL2326513 | — | — | 1 | 5.16 |
| CHEMBL2326517 | — | — | 1 | 5.14 |
| CHEMBL2326522 | — | — | 1 | 5.13 |
| CHEMBL2326518 | — | — | 1 | 5.09 |
| CHEMBL2326514 | — | — | 1 | 5.09 |
| CHEMBL2326519 | — | — | 1 | 5.07 |
| CHEMBL2326515 | — | — | 1 | 5.05 |
| CHEMBL2326520 | — | — | 1 | 5.05 |
| CHEMBL2321923 | — | — | 1 | 4.04 |
| CHEMBL2326506 | — | — | 1 | 4.04 |
| CHEMBL2326508 | — | — | 1 | 4.03 |
| CHEMBL2326507 | — | — | 1 | 4.00 |
| CHEMBL2326512 | — | — | 1 | - |
| CHEMBL2326510 | — | — | 1 | - |
| CHEMBL2326509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572366 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL6466 | COUMARIN | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL2326516 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL2326521 | — | Ki | = | 6710.0 | nM | 5.17 |
| CHEMBL2326511 | — | Ki | = | 6780.0 | nM | 5.17 |
| CHEMBL2326513 | — | Ki | = | 6860.0 | nM | 5.16 |
| CHEMBL2326517 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL2326522 | — | Ki | = | 7470.0 | nM | 5.13 |
| CHEMBL2326518 | — | Ki | = | 8110.0 | nM | 5.09 |
| CHEMBL2326514 | — | Ki | = | 8050.0 | nM | 5.09 |
| CHEMBL2326519 | — | Ki | = | 8430.0 | nM | 5.07 |
| CHEMBL2326515 | — | Ki | = | 8880.0 | nM | 5.05 |
| CHEMBL2326520 | — | Ki | = | 8930.0 | nM | 5.05 |
| CHEMBL2321923 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL2326506 | — | Ki | = | 91000.0 | nM | 4.04 |
| CHEMBL2326508 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL2326507 | — | Ki | = | 99000.0 | nM | 4.00 |
| CHEMBL2326512 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2326510 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2326509 | — | Ki | > | 100000.0 | nM | - |