Assay Detail
Binding
CHEMBL2329656
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Inhibition of rat SGLT2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.56 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323695 | — | — | 1 | 5.94 |
| CHEMBL2323694 | — | — | 1 | 5.37 |
| CHEMBL2159101 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323695 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL2323694 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL2159101 | — | IC50 | = | 4370.0 | nM | 5.36 |