Assay Detail
Functional
CHEMBL2329693
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Antitrypanosomal activity against Trypanosoma brucei brucei 221 after 48 hrs by Cell Titre Glo assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 52 | 6.32 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322969 | — | — | 1 | 8.22 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.92 |
| CHEMBL2325801 | — | — | 1 | 7.70 |
| CHEMBL2322979 | — | — | 1 | 7.57 |
| CHEMBL2325221 | — | — | 1 | 7.39 |
| CHEMBL2324280 | — | — | 1 | 7.24 |
| CHEMBL2324281 | — | — | 1 | 6.96 |
| CHEMBL2325802 | — | — | 1 | 6.92 |
| CHEMBL2322971 | — | — | 1 | 6.92 |
| CHEMBL2324282 | — | — | 1 | 6.85 |
| CHEMBL2322975 | — | — | 1 | 6.80 |
| CHEMBL2322968 | — | — | 1 | 6.77 |
| CHEMBL2325795 | — | — | 1 | 6.72 |
| CHEMBL2324283 | — | — | 1 | 6.72 |
| CHEMBL2324284 | — | — | 1 | 6.66 |
| CHEMBL2325803 | — | — | 1 | 6.66 |
| CHEMBL2322977 | — | — | 1 | 6.62 |
| CHEMBL2322976 | — | — | 1 | 6.60 |
| CHEMBL2325804 | — | — | 1 | 6.52 |
| CHEMBL2324285 | — | — | 1 | 6.51 |
| CHEMBL2322978 | — | — | 1 | 6.50 |
| CHEMBL2324286 | — | — | 1 | 6.48 |
| CHEMBL2324287 | — | — | 1 | 6.33 |
| CHEMBL2325781 | — | — | 1 | 6.32 |
| CHEMBL2324288 | — | — | 1 | 6.30 |
| CHEMBL2324289 | — | — | 1 | 6.28 |
| CHEMBL2324290 | — | — | 1 | 6.19 |
| CHEMBL2322970 | — | — | 1 | 6.17 |
| CHEMBL2324291 | — | — | 1 | 6.14 |
| CHEMBL2324292 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322969 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2325801 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2322979 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2325221 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2324280 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2324281 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2325802 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2322971 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2324282 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2322975 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2322968 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2325795 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2324283 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2325803 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2324284 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2322977 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2322976 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2325804 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2324285 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2322978 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2324286 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2324287 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2325781 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2324288 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2324289 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2324290 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2322970 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2324291 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2324292 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2324293 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL591552 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2325786 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2325794 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2325800 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2325799 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2325789 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2325788 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2322972 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2325790 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2325791 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2324296 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2325792 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2325787 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL2325793 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2325798 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL2325797 | — | EC50 | > | 16000.0 | nM | - |
| CHEMBL2325796 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2324294 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2322973 | — | EC50 | > | 10000.0 | nM | - |