Assay Detail
Binding
CHEMBL2329809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX1 (unknown origin)-mediated oxidation of N,N,N,Ntetramethyl-1,4-phenylenediamine using arachidonic acid as substrate by colorimetric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.56 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.70 |
| CHEMBL2323522 | — | — | 1 | 6.12 |
| CHEMBL2323490 | — | — | 1 | 5.66 |
| CHEMBL178687 | — | — | 1 | 4.31 |
| CHEMBL2323507 | — | — | 1 | 4.00 |
| CHEMBL2323511 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2323522 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2323490 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL178687 | — | IC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL2323507 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2323511 | — | IC50 | > | 100000.0 | nM | - |