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Assay Detail

CHEMBL2329940

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Functional
Antagonist activity at OATP1B1 (unknown origin) by [35S]GTPgammaS binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.
Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H.
J Med Chem (2013) 56 : 1946 -1960
PubMed 23409871 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.40 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2018969 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2018969 IC50 = 398.11 nM 6.40