Assay Detail
Binding
CHEMBL2329945
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Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Colloidal aggregation causes inhibition of G protein-coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.96 | 5.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324200 | Tetra-iodophenolphthalein | — | 2 | 5.00 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 2 | 4.94 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | - |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324200 | Tetra-iodophenolphthalein | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2324200 | Tetra-iodophenolphthalein | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL50 | QUERCETIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL50 | QUERCETIN | IC50 | > | 31622.78 | nM | - |
| CHEMBL104 | CLOTRIMAZOLE | Inhibition | - | % | - |