Assay Detail
Binding
CHEMBL2329985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal hexahistidine-tagged HGPRT
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hypoxanthine-guanine phosphoribosyltransferase (CHEMBL2360) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.04 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325752 | — | — | 1 | 7.52 |
| CHEMBL2325754 | — | — | 1 | 6.22 |
| CHEMBL2325753 | — | — | 1 | 6.00 |
| CHEMBL2325755 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325752 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2325754 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL2325753 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL2325755 | — | Ki | = | 37000.0 | nM | 4.43 |