Assay Detail
Functional
CHEMBL2329987
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Cytotoxicity against human NCI-H187 cells assessed as growth inhibition after 4 days by WST assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H187 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.81 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325764 | — | — | 1 | 8.85 |
| CHEMBL2325763 | — | — | 1 | 8.10 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.42 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325764 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2325763 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 38.4 | nM | 7.42 |
| CHEMBL376408 | ABT 737 | IC50 | = | 137.7 | nM | 6.86 |