Assay Detail
Binding
CHEMBL2330189
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Inhibition of Escherichia coli HldE-kinase preincubated for 30 mins prior to substrate addition measured after 30 mins by luminescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325152 | — | — | 1 | 9.00 |
| CHEMBL2325156 | — | — | 1 | 7.80 |
| CHEMBL2312560 | — | — | 1 | 7.72 |
| CHEMBL2325159 | — | — | 1 | 7.60 |
| CHEMBL2325158 | — | — | 1 | 7.52 |
| CHEMBL2325155 | — | — | 1 | 7.48 |
| CHEMBL2325142 | — | — | 1 | 7.26 |
| CHEMBL2325154 | — | — | 1 | 7.16 |
| CHEMBL2325157 | — | — | 1 | 7.15 |
| CHEMBL2325144 | — | — | 1 | 7.09 |
| CHEMBL2325141 | — | — | 1 | 7.01 |
| CHEMBL2325147 | — | — | 1 | 6.96 |
| CHEMBL2325148 | — | — | 1 | 6.96 |
| CHEMBL2325139 | — | — | 1 | 6.38 |
| CHEMBL2325149 | — | — | 1 | 6.29 |
| CHEMBL2325153 | — | — | 1 | 6.28 |
| CHEMBL2325150 | — | — | 1 | 6.24 |
| CHEMBL2325151 | — | — | 1 | 6.20 |
| CHEMBL2325140 | — | — | 1 | 6.18 |
| CHEMBL2325143 | — | — | 1 | 6.11 |
| CHEMBL2325145 | — | — | 1 | 6.06 |
| CHEMBL2325146 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325152 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2325156 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2312560 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2325159 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2325158 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2325155 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2325142 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2325154 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2325157 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2325144 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2325141 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2325147 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2325148 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2325139 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2325149 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2325153 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2325150 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2325151 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2325140 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2325143 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2325145 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL2325146 | — | IC50 | = | 1400.0 | nM | 5.85 |