Compound Detail
CHEMBL2325141
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NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](Cn4cc(CNC(=O)COc5ccc6sc(CNc7nncc(-c8c(Cl)cccc8Cl)n7)nc6c5)nn4)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL2325141 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QNDUKFPYTHQWQZ-MRVUHWHESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1008.9
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.01 | 7.01 | 98.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 98.0 | nM | 7.01 | Inhibition of Escherichia coli HldE-kinase preincubated for 30 mins prior to sub... | 23445125 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23445125 | 10.1021/jm400097h | Escherichia coli | 4 |
| 23445125 | 10.1021/jm400097h | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine