Assay Detail
Binding
CHEMBL2330224
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Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.73 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326360 | — | — | 1 | 5.20 |
| CHEMBL2326361 | — | — | 1 | 4.87 |
| CHEMBL2326359 | — | — | 1 | 4.66 |
| CHEMBL2326358 | — | — | 1 | 4.49 |
| CHEMBL2326356 | — | — | 1 | 4.43 |
| CHEMBL2326357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326360 | — | Ki | = | 6310.0 | nM | 5.20 |
| CHEMBL2326361 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL2326359 | — | Ki | = | 21900.0 | nM | 4.66 |
| CHEMBL2326358 | — | Ki | = | 32500.0 | nM | 4.49 |
| CHEMBL2326356 | — | Ki | = | 36700.0 | nM | 4.43 |
| CHEMBL2326357 | — | Ki | = | 138000.0 | nM | - |