Assay Detail
Functional
CHEMBL2330469
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Cytotoxicity against human primary CLL cells after 96 hrs by annexin V/propidium iodide staining-based FACS flow cytometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CLL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 9.10 | 10.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324629 | — | — | 1 | 10.43 |
| CHEMBL2321905 | — | — | 1 | 10.01 |
| CHEMBL2324630 | — | — | 1 | 9.77 |
| CHEMBL2324628 | — | — | 1 | 9.02 |
| CHEMBL215032 | — | — | 1 | 8.89 |
| CHEMBL2324626 | — | — | 1 | 8.68 |
| CHEMBL2324627 | — | — | 1 | 8.52 |
| CHEMBL2324625 | — | — | 1 | 8.33 |
| CHEMBL2324624 | — | — | 1 | 8.21 |
| CHEMBL2324632 | — | — | 1 | - |
| CHEMBL2324631 | — | — | 1 | - |
| CHEMBL1993268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324629 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL2321905 | — | IC50 | = | 0.098 | nM | 10.01 |
| CHEMBL2324630 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL2324628 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL215032 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2324626 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2324627 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2324625 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2324624 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2324632 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2324631 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1993268 | — | IC50 | > | 20000.0 | nM | - |