Assay Detail
Binding
CHEMBL2330504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human RXRalpha activity expressed in COS1 cells after 12 hrs by RXRE-luciferase reporter gene assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 5.14 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288436 | — | — | 1 | 7.40 |
| CHEMBL2172208 | — | — | 1 | 5.38 |
| CHEMBL2172212 | — | — | 1 | 5.36 |
| CHEMBL242857 | — | — | 1 | 5.32 |
| CHEMBL2326683 | — | — | 1 | 5.16 |
| CHEMBL2322964 | — | — | 1 | 5.08 |
| CHEMBL213072 | — | — | 1 | 5.06 |
| CHEMBL2322955 | — | — | 1 | 5.04 |
| CHEMBL425544 | — | — | 1 | 5.02 |
| CHEMBL2324622 | — | — | 1 | 5.00 |
| CHEMBL2322288 | — | — | 1 | 4.97 |
| CHEMBL1181663 | — | — | 1 | 4.95 |
| CHEMBL1182248 | — | — | 1 | 4.91 |
| CHEMBL2172210 | — | — | 1 | 4.82 |
| CHEMBL1181674 | — | — | 1 | 4.80 |
| CHEMBL1185123 | — | — | 1 | 4.79 |
| CHEMBL2322286 | — | — | 1 | 4.73 |
| CHEMBL2323836 | — | — | 1 | 4.71 |
| CHEMBL2322954 | — | — | 1 | - |
| CHEMBL2172206 | — | — | 1 | - |
| CHEMBL242413 | — | — | 1 | - |
| CHEMBL121622 | — | — | 1 | - |
| CHEMBL244759 | — | — | 1 | - |
| CHEMBL2172218 | — | — | 1 | - |
| CHEMBL2172214 | — | — | 1 | - |
| CHEMBL2172216 | — | — | 1 | - |
| CHEMBL2312904 | — | — | 1 | - |
| CHEMBL2172209 | — | — | 1 | - |
| CHEMBL382475 | — | — | 1 | - |
| CHEMBL2322957 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288436 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2172208 | — | EC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL2172212 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL242857 | — | EC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL2326683 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2322964 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL213072 | — | EC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL2322955 | — | EC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL425544 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL2324622 | — | EC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL2322288 | — | EC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL1181663 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1182248 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL2172210 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1181674 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL1185123 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL2322286 | — | EC50 | = | 18440.0 | nM | 4.73 |
| CHEMBL2323836 | — | EC50 | = | 19460.0 | nM | 4.71 |
| CHEMBL2312571 | — | EC50 | > | 44500.0 | nM | - |
| CHEMBL2322965 | — | EC50 | - | — | - | |
| CHEMBL2323837 | — | EC50 | - | — | - | |
| CHEMBL2321897 | — | EC50 | - | — | - | |
| CHEMBL2323838 | — | EC50 | - | — | - | |
| CHEMBL2322285 | — | EC50 | - | — | - | |
| CHEMBL2322290 | — | EC50 | - | — | - | |
| CHEMBL207901 | — | EC50 | - | — | - | |
| CHEMBL2322956 | — | EC50 | - | — | - | |
| CHEMBL2322957 | — | EC50 | - | — | - | |
| CHEMBL382475 | — | EC50 | - | — | - | |
| CHEMBL2172209 | — | EC50 | - | — | - | |
| CHEMBL2312904 | — | EC50 | > | 20700.0 | nM | - |
| CHEMBL2172216 | — | EC50 | - | — | - | |
| CHEMBL2172214 | — | EC50 | > | 34700.0 | nM | - |
| CHEMBL2172218 | — | EC50 | - | — | - | |
| CHEMBL244759 | — | EC50 | - | — | - | |
| CHEMBL121622 | — | EC50 | - | — | - | |
| CHEMBL242413 | — | EC50 | - | — | - | |
| CHEMBL2172206 | — | EC50 | - | — | - | |
| CHEMBL2322954 | — | EC50 | - | — | - |