Assay Detail
Binding
CHEMBL2330620
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Inhibition of PI3K p110beta (unknown origin)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.16 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322242 | — | — | 1 | 6.87 |
| CHEMBL2322233 | — | — | 1 | 6.86 |
| CHEMBL2322230 | — | — | 1 | 6.82 |
| CHEMBL2322225 | — | — | 1 | 6.79 |
| CHEMBL2326971 | — | — | 1 | 6.76 |
| CHEMBL2326954 | — | — | 1 | 6.71 |
| CHEMBL2322228 | — | — | 1 | 6.67 |
| CHEMBL2326956 | — | — | 1 | 6.62 |
| CHEMBL2326955 | — | — | 1 | 6.61 |
| CHEMBL2322244 | — | — | 1 | 6.51 |
| CHEMBL2322243 | — | — | 1 | 6.43 |
| CHEMBL2322229 | — | — | 1 | 6.43 |
| CHEMBL2322239 | — | — | 1 | 6.42 |
| CHEMBL2322232 | — | — | 1 | 6.38 |
| CHEMBL2326951 | — | — | 1 | 6.36 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.25 |
| CHEMBL2322226 | — | — | 1 | 6.25 |
| CHEMBL2322234 | — | — | 1 | 6.20 |
| CHEMBL2322245 | — | — | 1 | 6.16 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.13 |
| CHEMBL2322240 | — | — | 1 | 5.99 |
| CHEMBL2326965 | — | — | 1 | 5.93 |
| CHEMBL2326969 | — | — | 1 | 5.92 |
| CHEMBL2326952 | — | — | 1 | 5.76 |
| CHEMBL2322241 | — | — | 1 | 5.59 |
| CHEMBL2326967 | — | — | 1 | 5.56 |
| CHEMBL2326953 | — | — | 1 | 5.44 |
| CHEMBL2326968 | — | — | 1 | 5.28 |
| CHEMBL2322227 | — | — | 1 | 5.15 |
| CHEMBL2322236 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322242 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL2322233 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2322230 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2322225 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL2326971 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL2326954 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL2322228 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL2326956 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2326955 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL2322244 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2322243 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL2322229 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL2322239 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL2322232 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL2326951 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL2322226 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL2322234 | — | IC50 | = | 632.0 | nM | 6.20 |
| CHEMBL2322245 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL98350 | LY-294002 | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL2322240 | — | IC50 | = | 1027.0 | nM | 5.99 |
| CHEMBL2326965 | — | IC50 | = | 1161.0 | nM | 5.93 |
| CHEMBL2326969 | — | IC50 | = | 1205.0 | nM | 5.92 |
| CHEMBL2326952 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2322241 | — | IC50 | = | 2554.0 | nM | 5.59 |
| CHEMBL2326967 | — | IC50 | = | 2757.0 | nM | 5.56 |
| CHEMBL2326953 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2326968 | — | IC50 | = | 5241.0 | nM | 5.28 |
| CHEMBL2322227 | — | IC50 | = | 7047.0 | nM | 5.15 |
| CHEMBL2322236 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL2322246 | — | IC50 | = | 9247.0 | nM | 5.03 |
| CHEMBL2326970 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2322231 | — | IC50 | > | 50000.0 | nM | - |