Assay Detail
Binding
CHEMBL2330633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.59 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325704 | — | — | 1 | 6.03 |
| CHEMBL2325705 | — | — | 1 | 5.85 |
| CHEMBL2325703 | — | — | 1 | 5.80 |
| CHEMBL2325706 | — | — | 1 | 5.57 |
| CHEMBL2030442 | — | — | 1 | 5.42 |
| CHEMBL2325697 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325704 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL2325705 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2325703 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2325706 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2030442 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2325697 | — | IC50 | = | 13000.0 | nM | 4.89 |