Assay Detail
Functional
CHEMBL2330686
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Agonist activity at rat MOR expressed in rat C6 cells assessed as stimulation of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.74 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322563 | — | — | 1 | 9.62 |
| CHEMBL2322562 | — | — | 1 | 9.28 |
| CHEMBL2322561 | — | — | 1 | 9.08 |
| CHEMBL2322560 | — | — | 1 | 8.96 |
| CHEMBL2322568 | — | — | 1 | 8.80 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322563 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL2322562 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL2322561 | — | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL2322560 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2322568 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL70 | MORPHINE | EC50 | = | 194.0 | nM | 6.71 |