Assay Detail
Binding
CHEMBL2330743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by patch clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.56 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324256 | — | — | 1 | 6.84 |
| CHEMBL2325199 | — | — | 1 | 6.71 |
| CHEMBL2325200 | — | — | 1 | 6.67 |
| CHEMBL2325205 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324256 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL2325199 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2325200 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL2325205 | — | IC50 | = | 962.0 | nM | 6.02 |