Compound Detail
CHEMBL2324256
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Basic Information
| ChEMBL ID | CHEMBL2324256 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QFABWSMCBRDEAQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
390.5
MW (Da)
5.30
ALogP
4
HBA
1
HBD
57.4
PSA (Ų)
0.48
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 6.84 | 6.805 | 146.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 146.0 | nM | 6.84 | Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by pa... | 23473309 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 170.0 | nM | 6.77 | Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cel... | 23473309 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23473309 | 10.1021/jm301564f | Voltage-gated inwardly rectifying potassium channel KCNH2 | 3 |
Data from ChEMBL 36 via Core Engine