Assay Detail
Binding
CHEMBL2330875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells by ionworks assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.93 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325984 | — | — | 1 | 5.80 |
| CHEMBL2325983 | — | — | 1 | 5.58 |
| CHEMBL2325985 | — | — | 1 | 5.46 |
| CHEMBL598194 | — | — | 1 | 5.28 |
| CHEMBL2325982 | — | — | 1 | 5.19 |
| CHEMBL2325743 | — | — | 1 | 5.17 |
| CHEMBL2325997 | — | — | 1 | 5.14 |
| CHEMBL2325742 | — | — | 1 | 5.04 |
| CHEMBL2325740 | — | — | 1 | 5.03 |
| CHEMBL2325728 | — | — | 1 | 4.68 |
| CHEMBL2325987 | — | — | 1 | 4.57 |
| CHEMBL2325729 | — | — | 1 | 4.53 |
| CHEMBL2325739 | — | — | 1 | 4.24 |
| CHEMBL2325995 | — | — | 1 | 4.13 |
| CHEMBL2325736 | — | — | 1 | 4.10 |
| CHEMBL2325994 | — | — | 1 | - |
| CHEMBL2325993 | — | — | 1 | - |
| CHEMBL2325992 | — | — | 1 | - |
| CHEMBL2325991 | — | — | 1 | - |
| CHEMBL2325732 | — | — | 1 | - |
| CHEMBL2325989 | — | — | 1 | - |
| CHEMBL2325988 | — | — | 1 | - |
| CHEMBL2325986 | — | — | 1 | - |
| CHEMBL2325733 | — | — | 1 | - |
| CHEMBL2325734 | — | — | 1 | - |
| CHEMBL2325735 | — | — | 1 | - |
| CHEMBL2325737 | — | — | 1 | - |
| CHEMBL2325738 | — | — | 1 | - |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | - |
| CHEMBL2325990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325984 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2325983 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2325985 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL598194 | — | IC50 | = | 5235.0 | nM | 5.28 |
| CHEMBL2325982 | — | IC50 | = | 6495.0 | nM | 5.19 |
| CHEMBL2325743 | — | IC50 | = | 6747.0 | nM | 5.17 |
| CHEMBL2325997 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2325742 | — | IC50 | = | 9092.0 | nM | 5.04 |
| CHEMBL2325740 | — | IC50 | = | 9369.0 | nM | 5.03 |
| CHEMBL2325728 | — | IC50 | = | 21030.0 | nM | 4.68 |
| CHEMBL2325987 | — | IC50 | = | 26957.0 | nM | 4.57 |
| CHEMBL2325729 | — | IC50 | = | 29367.0 | nM | 4.53 |
| CHEMBL2325739 | — | IC50 | = | 57793.0 | nM | 4.24 |
| CHEMBL2325995 | — | IC50 | = | 74807.0 | nM | 4.13 |
| CHEMBL2325736 | — | IC50 | = | 80124.0 | nM | 4.10 |
| CHEMBL2325731 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325730 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325727 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325996 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325994 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325993 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325992 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325991 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325732 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325989 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325988 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325986 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325733 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325734 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325735 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL2325737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325741 | CAPIVASERTIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL2325990 | — | IC50 | > | 33300.0 | nM | - |