Assay Detail
Binding
CHEMBL2330883
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Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.42 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325728 | — | — | 1 | 7.37 |
| CHEMBL2325729 | — | — | 1 | 7.11 |
| CHEMBL2325996 | — | — | 1 | 7.09 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 7.05 |
| CHEMBL2325738 | — | — | 1 | 7.04 |
| CHEMBL2325992 | — | — | 1 | 7.02 |
| CHEMBL2325727 | — | — | 1 | 6.96 |
| CHEMBL2325993 | — | — | 1 | 6.90 |
| CHEMBL2325743 | — | — | 1 | 6.87 |
| CHEMBL2325739 | — | — | 1 | 6.86 |
| CHEMBL2325982 | — | — | 1 | 6.84 |
| CHEMBL2325995 | — | — | 1 | 6.81 |
| CHEMBL2325997 | — | — | 1 | 6.71 |
| CHEMBL2325983 | — | — | 1 | 6.68 |
| CHEMBL2325994 | — | — | 1 | 6.68 |
| CHEMBL2325740 | — | — | 1 | 6.52 |
| CHEMBL2325737 | — | — | 1 | 6.52 |
| CHEMBL598194 | — | — | 1 | 6.48 |
| CHEMBL2325736 | — | — | 1 | 6.38 |
| CHEMBL2325733 | — | — | 1 | 6.31 |
| CHEMBL2325731 | — | — | 1 | 6.17 |
| CHEMBL2325734 | — | — | 1 | 6.06 |
| CHEMBL2325735 | — | — | 1 | 6.00 |
| CHEMBL2325730 | — | — | 1 | 5.95 |
| CHEMBL2325984 | — | — | 1 | 5.79 |
| CHEMBL2325985 | — | — | 1 | 5.78 |
| CHEMBL2325987 | — | — | 1 | 5.75 |
| CHEMBL2325732 | — | — | 1 | 5.54 |
| CHEMBL2325742 | — | — | 1 | 5.34 |
| CHEMBL2325990 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325728 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2325729 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2325996 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2325741 | CAPIVASERTIB | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2325738 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2325992 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2325727 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2325993 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL2325743 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL2325739 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL2325982 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2325995 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL2325997 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL2325983 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL2325994 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL2325740 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL2325737 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL598194 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL2325736 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL2325733 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL2325731 | — | IC50 | = | 681.0 | nM | 6.17 |
| CHEMBL2325734 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL2325735 | — | IC50 | = | 995.0 | nM | 6.00 |
| CHEMBL2325730 | — | IC50 | = | 1126.0 | nM | 5.95 |
| CHEMBL2325984 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL2325985 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL2325987 | — | IC50 | = | 1776.0 | nM | 5.75 |
| CHEMBL2325732 | — | IC50 | = | 2893.0 | nM | 5.54 |
| CHEMBL2325742 | — | IC50 | = | 4594.0 | nM | 5.34 |
| CHEMBL2325990 | — | IC50 | = | 5165.0 | nM | 5.29 |
| CHEMBL2325986 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL2325989 | — | IC50 | > | 3250.0 | nM | - |
| CHEMBL2325988 | — | IC50 | > | 30132.0 | nM | - |
| CHEMBL2325991 | — | IC50 | > | 3250.0 | nM | - |