Assay Detail
Binding
CHEMBL2330884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Akt3 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.18 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325993 | — | — | 1 | 8.40 |
| CHEMBL2325729 | — | — | 1 | 8.22 |
| CHEMBL2325992 | — | — | 1 | 8.15 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 8.10 |
| CHEMBL2325996 | — | — | 1 | 8.00 |
| CHEMBL2325995 | — | — | 1 | 7.82 |
| CHEMBL2325738 | — | — | 1 | 7.82 |
| CHEMBL2325982 | — | — | 1 | 7.82 |
| CHEMBL2325743 | — | — | 1 | 7.80 |
| CHEMBL2325728 | — | — | 1 | 7.75 |
| CHEMBL2325739 | — | — | 1 | 7.66 |
| CHEMBL2325983 | — | — | 1 | 7.62 |
| CHEMBL2325736 | — | — | 1 | 7.52 |
| CHEMBL2325997 | — | — | 1 | 7.52 |
| CHEMBL2325994 | — | — | 1 | 7.44 |
| CHEMBL2325737 | — | — | 1 | 7.40 |
| CHEMBL598194 | — | — | 1 | 7.24 |
| CHEMBL2325740 | — | — | 1 | 7.00 |
| CHEMBL2325730 | — | — | 1 | 6.98 |
| CHEMBL2325985 | — | — | 1 | 6.82 |
| CHEMBL2325987 | — | — | 1 | 6.75 |
| CHEMBL2325984 | — | — | 1 | 6.57 |
| CHEMBL2325742 | — | — | 1 | 6.28 |
| CHEMBL2325986 | — | — | 1 | 6.24 |
| CHEMBL2325990 | — | — | 1 | 6.12 |
| CHEMBL2325991 | — | — | 1 | 5.54 |
| CHEMBL2325988 | — | — | 1 | 5.37 |
| CHEMBL2325989 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325993 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2325729 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2325992 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2325741 | CAPIVASERTIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2325996 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2325995 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2325738 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2325982 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2325743 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2325728 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2325739 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2325983 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2325736 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2325997 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2325994 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2325737 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL598194 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2325740 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2325730 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2325985 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2325987 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL2325984 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2325742 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL2325986 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL2325990 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL2325991 | — | IC50 | = | 2893.0 | nM | 5.54 |
| CHEMBL2325988 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL2325989 | — | IC50 | = | 8065.0 | nM | 5.09 |