Assay Detail
Binding
CHEMBL2330885
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Akt2 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.98 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 8.10 |
| CHEMBL2325729 | — | — | 1 | 7.89 |
| CHEMBL2325992 | — | — | 1 | 7.85 |
| CHEMBL2325993 | — | — | 1 | 7.82 |
| CHEMBL2325743 | — | — | 1 | 7.70 |
| CHEMBL2325738 | — | — | 1 | 7.66 |
| CHEMBL2325982 | — | — | 1 | 7.64 |
| CHEMBL2325739 | — | — | 1 | 7.62 |
| CHEMBL2325983 | — | — | 1 | 7.52 |
| CHEMBL2325996 | — | — | 1 | 7.52 |
| CHEMBL2325728 | — | — | 1 | 7.51 |
| CHEMBL2325736 | — | — | 1 | 7.44 |
| CHEMBL2325997 | — | — | 1 | 7.40 |
| CHEMBL2325995 | — | — | 1 | 7.38 |
| CHEMBL2325737 | — | — | 1 | 7.34 |
| CHEMBL598194 | — | — | 1 | 7.18 |
| CHEMBL2325994 | — | — | 1 | 7.02 |
| CHEMBL2325740 | — | — | 1 | 6.89 |
| CHEMBL2325730 | — | — | 1 | 6.80 |
| CHEMBL2325985 | — | — | 1 | 6.72 |
| CHEMBL2325984 | — | — | 1 | 6.68 |
| CHEMBL2325987 | — | — | 1 | 6.46 |
| CHEMBL2325986 | — | — | 1 | 6.15 |
| CHEMBL2325990 | — | — | 1 | 6.09 |
| CHEMBL2325742 | — | — | 1 | 6.08 |
| CHEMBL2325988 | — | — | 1 | 5.09 |
| CHEMBL2325991 | — | — | 1 | 5.07 |
| CHEMBL2325989 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325741 | CAPIVASERTIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2325729 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2325992 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2325993 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2325743 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2325738 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2325982 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2325739 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2325983 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2325996 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2325728 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2325736 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2325997 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2325995 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2325737 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL598194 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2325994 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2325740 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2325730 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL2325985 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2325984 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2325987 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL2325986 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL2325990 | — | IC50 | = | 805.0 | nM | 6.09 |
| CHEMBL2325742 | — | IC50 | = | 836.0 | nM | 6.08 |
| CHEMBL2325988 | — | IC50 | = | 8111.0 | nM | 5.09 |
| CHEMBL2325991 | — | IC50 | = | 8578.0 | nM | 5.07 |
| CHEMBL2325989 | — | IC50 | = | 16498.0 | nM | 4.78 |