Assay Detail
Binding
CHEMBL2330912
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Inhibition of PKC-theta in human PBMC cells assessed as inhibition of IL-2 after 24 hrs by bead-based FLISA assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326000 | — | — | 1 | 9.00 |
| CHEMBL2326001 | — | — | 1 | 8.70 |
| CHEMBL2325998 | — | — | 1 | 8.40 |
| CHEMBL2326007 | — | — | 1 | 8.22 |
| CHEMBL2326002 | — | — | 1 | 7.96 |
| CHEMBL2325999 | — | — | 1 | 6.92 |
| CHEMBL2326012 | — | — | 1 | 6.77 |
| CHEMBL2326013 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326000 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2326001 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2325998 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2326007 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2326002 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2325999 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2326012 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2326013 | — | IC50 | = | 420.0 | nM | 6.38 |