Assay Detail
Binding
CHEMBL2330946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cells after 120 mins by scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.85 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322916 | — | — | 1 | 7.16 |
| CHEMBL2322917 | — | — | 1 | 7.12 |
| CHEMBL2322918 | — | — | 1 | 6.82 |
| CHEMBL2322925 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322916 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2322917 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL2322918 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2322925 | — | Ki | = | 510.0 | nM | 6.29 |