Assay Detail
Binding
CHEMBL2330982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNKS2 (unknown origin) by NAD+-dependent autopoly(ADP ribosyl)lation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Poly [ADP-ribose] polymerase tankyrase-2 (CHEMBL6154) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.63 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325503 | — | — | 1 | 7.60 |
| CHEMBL2325500 | — | — | 1 | 7.37 |
| CHEMBL2325497 | — | — | 1 | 7.29 |
| CHEMBL2325502 | — | — | 1 | 7.27 |
| CHEMBL2325499 | — | — | 1 | 6.54 |
| CHEMBL1552719 | — | — | 1 | 6.34 |
| CHEMBL2325498 | — | — | 1 | 5.75 |
| CHEMBL2325501 | — | — | 1 | 4.91 |
| CHEMBL2325496 | — | — | 1 | - |
| CHEMBL2325495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325503 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2325500 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2325497 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2325502 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2325499 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1552719 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2325498 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2325501 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL2325496 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2325495 | — | IC50 | > | 10000.0 | nM | - |