Assay Detail
Binding
CHEMBL2330993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-serine O-palmitoleoyltransferase porcupine (CHEMBL1255164) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The development of highly potent inhibitors for porcupine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 63 | 7.44 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323230 | — | — | 1 | 9.52 |
| CHEMBL2322627 | — | — | 1 | 9.52 |
| CHEMBL2323228 | — | — | 1 | 9.35 |
| CHEMBL2323231 | — | — | 1 | 9.30 |
| CHEMBL2322632 | — | — | 1 | 9.12 |
| CHEMBL2323233 | — | — | 1 | 9.00 |
| CHEMBL2322628 | — | — | 1 | 8.82 |
| CHEMBL2322624 | — | — | 1 | 8.82 |
| CHEMBL2322626 | — | — | 1 | 8.70 |
| CHEMBL2323229 | — | — | 1 | 8.52 |
| CHEMBL2322625 | — | — | 1 | 8.46 |
| CHEMBL2322629 | — | — | 1 | 8.46 |
| CHEMBL2322635 | — | — | 1 | 8.40 |
| CHEMBL2322623 | — | — | 1 | 8.26 |
| CHEMBL1581616 | — | — | 1 | 7.82 |
| CHEMBL2323232 | — | — | 1 | 7.82 |
| CHEMBL2324275 | — | — | 1 | 7.82 |
| CHEMBL2324274 | — | — | 1 | 7.60 |
| CHEMBL2322622 | — | — | 1 | 7.60 |
| CHEMBL1257090 | — | — | 1 | 7.60 |
| CHEMBL2324273 | — | — | 1 | 7.52 |
| CHEMBL1257064 | — | — | 1 | 7.52 |
| CHEMBL2323243 | — | — | 1 | 7.52 |
| CHEMBL2325505 | — | — | 1 | 7.52 |
| CHEMBL2325512 | — | — | 1 | 7.46 |
| CHEMBL2322620 | — | — | 1 | 7.46 |
| CHEMBL1257089 | — | — | 1 | 7.40 |
| CHEMBL2324266 | — | — | 1 | 7.40 |
| CHEMBL2324277 | — | — | 1 | 7.40 |
| CHEMBL2325509 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323230 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2322627 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2323228 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL2323231 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2322632 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL2323233 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2322628 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2322624 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2322626 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2323229 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2322625 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2322629 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2322635 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2322623 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2324275 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1581616 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2323232 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2324274 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2322622 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1257090 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2324273 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1257064 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2323243 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2325505 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2322620 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2325512 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1257089 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2324266 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2324277 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2325509 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2324279 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2325511 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2323239 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1257063 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2322631 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2324276 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2324265 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2325506 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2322621 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2324267 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2325513 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2322619 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2325510 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL2322630 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2325507 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2324278 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2323234 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2323238 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2324272 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2323237 | — | EC50 | = | 580.0 | nM | 6.24 |