Compound Detail
CHEMBL2325507
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O=C(CNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12)Nc1nc2ccc([N+](=O)[O-])cc2s1
Basic Information
| ChEMBL ID | CHEMBL2325507 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XAAUSVCQDOGWLT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
500.5
MW (Da)
3.27
ALogP
9
HBA
2
HBD
149.1
PSA (Ų)
0.27
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine CHEMBL1255164 | EC50 | 6.62 | 6.62 | 240.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine | EC50 | = | 240.0 | nM | 6.62 | Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by... | 23477365 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23477365 | 10.1021/jm400159c | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
Data from ChEMBL 36 via Core Engine