Assay Detail
Functional
CHEMBL2331001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream forms of wild type Trypanosoma brucei rhodesiense STIB900 after 70 hrs by Alamar Blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.05 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 9.22 |
| CHEMBL2322979 | — | — | 1 | 8.15 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.14 |
| CHEMBL2325221 | — | — | 1 | 7.96 |
| CHEMBL2322969 | — | — | 1 | 7.89 |
| CHEMBL2322976 | — | — | 1 | 7.16 |
| CHEMBL2322971 | — | — | 1 | 7.14 |
| CHEMBL2324280 | — | — | 1 | 6.85 |
| CHEMBL2325795 | — | — | 1 | 6.80 |
| CHEMBL2324282 | — | — | 1 | 6.77 |
| CHEMBL2324281 | — | — | 1 | 6.68 |
| CHEMBL2322975 | — | — | 1 | 6.64 |
| CHEMBL2325781 | — | — | 1 | 6.43 |
| CHEMBL2325789 | — | — | 1 | 5.82 |
| CHEMBL2325786 | — | — | 1 | 5.75 |
| CHEMBL2324296 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2322979 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL166 | MELARSOPROL | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2325221 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2322969 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2322976 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2322971 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2324280 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2325795 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2324282 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2324281 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2322975 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2325781 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2325789 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2325786 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2324296 | — | EC50 | = | 3800.0 | nM | 5.42 |