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Assay Detail

CHEMBL2339128

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FABP4 by 8-anilino-1-naphthalenesulfonic acid based fluorescence displacement assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty acid-binding protein, adipocyte (CHEMBL2083)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.
Beniyama Y, Matsuno K, Miyachi H.
Bioorg Med Chem Lett (2013) 23 : 1662 -1666
PubMed 23395658 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.11 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL247920 1 6.66
CHEMBL1782963 1 6.01
CHEMBL2334261 1 5.60
CHEMBL2334251 1 5.52
CHEMBL2334256 1 5.37
CHEMBL2334259 1 5.37
CHEMBL2334249 1 5.27
CHEMBL2334255 1 5.25
CHEMBL2334246 1 5.21
CHEMBL2334252 1 5.19
CHEMBL2334250 1 5.02
CHEMBL2334257 1 4.99
CHEMBL2334254 1 4.99
CHEMBL2334258 1 4.87
CHEMBL2334244 1 4.81
CHEMBL2334262 1 4.78
CHEMBL2334243 1 4.63
CHEMBL2334248 1 4.51
CHEMBL2334247 1 4.13
CHEMBL2334253 1 4.07
CHEMBL2334260 1 -
CHEMBL2331584 1 -
CHEMBL2334245 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL247920 IC50 = 221.0 nM 6.66
CHEMBL1782963 IC50 = 987.0 nM 6.01
CHEMBL2334261 IC50 = 2500.0 nM 5.60
CHEMBL2334251 IC50 = 3020.0 nM 5.52
CHEMBL2334256 IC50 = 4320.0 nM 5.37
CHEMBL2334259 IC50 = 4270.0 nM 5.37
CHEMBL2334249 IC50 = 5410.0 nM 5.27
CHEMBL2334255 IC50 = 5640.0 nM 5.25
CHEMBL2334246 IC50 = 6130.0 nM 5.21
CHEMBL2334252 IC50 = 6390.0 nM 5.19
CHEMBL2334250 IC50 = 9510.0 nM 5.02
CHEMBL2334257 IC50 = 10300.0 nM 4.99
CHEMBL2334254 IC50 = 10200.0 nM 4.99
CHEMBL2334258 IC50 = 13600.0 nM 4.87
CHEMBL2334244 IC50 = 15500.0 nM 4.81
CHEMBL2334262 IC50 = 16600.0 nM 4.78
CHEMBL2334243 IC50 = 23500.0 nM 4.63
CHEMBL2334248 IC50 = 31000.0 nM 4.51
CHEMBL2334247 IC50 = 74000.0 nM 4.13
CHEMBL2334253 IC50 = 86000.0 nM 4.07
CHEMBL2334260 IC50 - -
CHEMBL2331584 IC50 = 259000.0 nM -
CHEMBL2334245 IC50 > 10000000.0 nM -