Assay Detail
Binding
CHEMBL2339396
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Binding affinity to recombinant PIGF1 (unknown origin) measured for 60 seconds by surface plasmon resonance assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.53 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 8.09 |
| CHEMBL2335722 | — | — | 1 | 7.96 |
| CHEMBL499587 | GERANIN B | — | 1 | 7.64 |
| CHEMBL450916 | PROANTHOCYANIDIN A1 | — | 1 | 6.41 |
| CHEMBL286933 | PROANTHOCYANIDIN A2 | — | 1 | - |
| CHEMBL2335721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | Kd | = | 8.2 | nM | 8.09 |
| CHEMBL2335722 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL499587 | GERANIN B | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL450916 | PROANTHOCYANIDIN A1 | Kd | = | 394.0 | nM | 6.41 |
| CHEMBL286933 | PROANTHOCYANIDIN A2 | Kd | - | — | - | |
| CHEMBL2335721 | — | Kd | - | — | - |