Assay Detail
Binding
CHEMBL2339627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode voltage clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit rho-1 (CHEMBL3561) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of ρ1 GABAC Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446306 | — | — | 1 | 5.01 |
| CHEMBL2337889 | — | — | 1 | - |
| CHEMBL2337487 | — | — | 1 | - |
| CHEMBL2337486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446306 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL2337889 | — | IC50 | = | 147920.0 | nM | - |
| CHEMBL2337487 | — | IC50 | = | 103140.0 | nM | - |
| CHEMBL2337486 | — | IC50 | = | 281420.0 | nM | - |