Gamma-aminobutyric acid receptor subunit rho-1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P24046. Use UniProt P24046 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P24046 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit rho-1
Review this target as Gamma-aminobutyric acid receptor subunit rho-1, mapped to UniProt P24046. Sequence length is 479 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-aminobutyric acid receptor subunit rho-1 as ChEMBL target CHEMBL3561, mapped to UniProt P24046. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Gamma-aminobutyric acid receptor subunit rho-1 is the right protein anchor across sources, using UniProt P24046 as the stable mapping.
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| Preferred Name | Gamma-aminobutyric acid receptor subunit rho-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P24046 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit rho-1 |
| UniProt Accession | P24046 |
| Component Type | Protein |
| Sequence Length | 479 aa |
Gamma-aminobutyric acid receptor subunit rho-1
Review this target as Gamma-aminobutyric acid receptor subunit rho-1, mapped to UniProt P24046. Sequence length is 479 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL15891 | 7.04 | IC50 | 91.0 | Approved |
| CHEMBL96 | 6.57 | EC50 | 269.15 | Preclinical |
| CHEMBL33086 | 6.4 | EC50 | 400.0 | Preclinical |
| CHEMBL273481 | 6.16 | EC50 | 691.83 | Preclinical |
| CHEMBL1890408 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL4464494 | 5.92 | EC50 | 1200.0 | Preclinical |
| CHEMBL3322882 | 5.91 | EC50 | 1230.27 | Preclinical |
| CHEMBL3322886 | 5.8 | EC50 | 1584.89 | Preclinical |
| CHEMBL4442696 | 5.8 | EC50 | 1584.89 | Preclinical |
| CHEMBL397209 | 5.65 | IC50 | 2220.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 19 | 5.4 |
| single protein format | 4 | 7 | 5.6 |
| assay format | 2 | 8 | 4.8 |
| cell membrane format | 2 | 5 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 17 | 25 | 5.0 |
| assay format | 2 | 0 | — |