Compound Detail
CHEMBL15891
LINDANE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL15891 |
| Name | LINDANE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JLYXXMFPNIAWKQ-GNIYUCBRSA-N |
| Therapeutic | ✓ Yes |
11
Targets
11
Activities
1
Assay Types
0
PK Parameters
20
Publications
22
Known Names
2
Indications
2
Mechanisms
Molecular Properties
290.8
MW (Da)
3.64
ALogP
0
HBA
0
HBD
0.0
PSA (Ų)
0.60
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1974 |
| Availability | Withdrawn |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| GABA-A receptor negative allosteric modulator | NEGATIVE ALLOSTERIC MODULATOR | GABA-A receptor | ✓ | ✓ |
| GABA-A receptor negative allosteric modulator | NEGATIVE ALLOSTERIC MODULATOR | GABA-A receptor | ✓ | ✓ |
Indications
Ectoparasitic Infestations Lice Infestations
ATC Classification
P03AB02
lindane
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
Drug Warnings
Withdrawn
General Warning
potential to cause toxic effects
Withdrawn
General Warning
Toxic effects on environment and human health
Black Box Warning
neurotoxicity
Activity Summary
IC50 11 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta-3 CHEMBL1847 | IC50 | 9.05 | 9.05 | 0.9 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 CHEMBL3885578 | IC50 | 8.89 | 8.89 | 1.3 | 1 |
| GABA-A receptor; alpha-6/beta-3/gamma-2 CHEMBL2095190 | IC50 | 8.31 | 8.31 | 4.9 | 1 |
| GABA receptor subunit CHEMBL3986 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| GABA-A receptor alpha-1/beta-3 CHEMBL4106151 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 CHEMBL2094121 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
| GABA A receptor alpha-1/beta-1/gamma-2 CHEMBL2111392 | IC50 | 7.17 | 7.17 | 67.0 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-1 CHEMBL3561 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1/ beta-1 CHEMBL3885570 | IC50 | 6.95 | 6.95 | 112.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.51 | 6.51 | 306.0 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 4.39 | 4.39 | 40738.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 19642076 | 10.1002/ps.1818 | Ceutorhynchus obstrictus | 4 |
| 12428955 | 10.1021/jf025857p | Spodoptera littoralis | 4 |
| 12590481 | 10.1021/jf025892w | Leaf | 3 |
| 12428955 | 10.1021/jf025857p | Leptinotarsa decemlineata | 3 |
| 12590481 | 10.1021/jf025892w | Stem | 3 |
| 12590481 | 10.1021/jf025892w | Root | 3 |
| 12590481 | 10.1021/jf025892w | Unchecked | 3 |
| - | 10.1584/jpestics.R07-07 | Unchecked | 2 |
| 20553011 | 10.1021/tx1000865 | Hepatotoxicity | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 12590481 | 10.1021/jf025892w | Fruit | 2 |
| 12428955 | 10.1021/jf025857p | ADMET | 1 |
| 12428955 | 10.1021/jf025857p | Rhopalosiphum padi | 1 |
| 12428955 | 10.1021/jf025857p | CHO | 1 |
| 18834112 | 10.1021/jm800656v | Amine oxidase [flavin-containing] A | 1 |
| 16134935 | 10.1021/jm050403f | Androgen receptor | 1 |
Data from ChEMBL 36 via Core Engine