Assay Detail
Binding
CHEMBL3073010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]EBOB from recombinant Homo sapiens (human) GABA alpha1beta1gamma2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA A receptor alpha-1/beta-1/gamma-2 (CHEMBL2111392) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Insecticide interactions with -aminobutyric acid and nicotinic receptors: predictive aspects of structural models
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.71 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1890408 | ALPHA-ENDOSULFAN | — | 1 | 7.40 |
| CHEMBL15891 | LINDANE | 4.0 | 1 | 7.17 |
| CHEMBL101326 | FIPRONIL | -1.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1890408 | ALPHA-ENDOSULFAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL15891 | LINDANE | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL101326 | FIPRONIL | IC50 | = | 2800.0 | nM | 5.55 |