GABA-A receptor alpha-1/beta-3 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P14867. Use UniProt P14867 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14867 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit alpha-1
Review this target as GABA-A receptor alpha-1/beta-3, mapped to UniProt P14867. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-1. Sequence length is 456 aa.
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This review treats GABA-A receptor alpha-1/beta-3 as ChEMBL target CHEMBL4106151, mapped to UniProt P14867. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GABA-A receptor alpha-1/beta-3 is the right protein anchor across sources, using UniProt P14867 as the stable mapping.
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| Preferred Name | GABA-A receptor alpha-1/beta-3 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P14867 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-1 |
| UniProt Accession | P14867 |
| Component Type | Protein |
| Sequence Length | 456 aa |
Gamma-aminobutyric acid receptor subunit alpha-1
Review this target as GABA-A receptor alpha-1/beta-3, mapped to UniProt P14867. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-1. Sequence length is 456 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1890408 | 8.08 | IC50 | 8.3 | Preclinical |
| CHEMBL15891 | 7.92 | IC50 | 12.0 | Approved |
| CHEMBL101326 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL4748423 | 5.54 | EC50 | 2900.0 | Preclinical |
| CHEMBL16901 | 4.22 | EC50 | 59600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 1 | 4.2 |
| assay format | 1 | 3 | 7.8 |
| cell membrane format | 1 | 1 | 5.5 |