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Assay Detail

CHEMBL2339686

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human EC109 cells assessed as growth inhibition after 72 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ECa-109
Confidence 1 — Organism
Curated By Autocuration

Publication

Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents.
Duan YC, Ma YC, Zhang E, Shi XJ, Wang MM, Ye XW, Liu HM.
Eur J Med Chem (2013) 62 : 11 -19
PubMed 23353743 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 4.58 5.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2334497 1 5.61
CHEMBL185 FLUOROURACIL 4.0 1 5.48
CHEMBL2334499 1 4.92
CHEMBL2334484 1 4.57
CHEMBL2334490 1 4.53
CHEMBL2334485 1 4.49
CHEMBL2334488 1 4.49
CHEMBL2334502 1 4.43
CHEMBL2334504 1 4.35
CHEMBL2334501 1 4.32
CHEMBL2334486 1 4.25
CHEMBL2334489 1 4.24
CHEMBL2334498 1 4.23
CHEMBL2334494 1 4.16
CHEMBL2334496 1 -
CHEMBL2334495 1 -
CHEMBL2334493 1 -
CHEMBL2334492 1 -
CHEMBL2334491 1 -
CHEMBL2334487 1 -
CHEMBL2334192 1 -
CHEMBL2334191 1 -
CHEMBL2334190 1 -
CHEMBL2334189 1 -
CHEMBL2334188 1 -
CHEMBL2334187 1 -
CHEMBL2334505 1 -
CHEMBL2334500 1 -
CHEMBL2334503 1 -
CHEMBL2334193 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2334497 IC50 = 2440.0 nM 5.61
CHEMBL185 FLUOROURACIL IC50 = 3340.0 nM 5.48
CHEMBL2334499 IC50 = 11930.0 nM 4.92
CHEMBL2334484 IC50 = 26960.0 nM 4.57
CHEMBL2334490 IC50 = 29410.0 nM 4.53
CHEMBL2334485 IC50 = 32030.0 nM 4.49
CHEMBL2334488 IC50 = 32560.0 nM 4.49
CHEMBL2334502 IC50 = 36840.0 nM 4.43
CHEMBL2334504 IC50 = 44390.0 nM 4.35
CHEMBL2334501 IC50 = 47860.0 nM 4.32
CHEMBL2334486 IC50 = 56790.0 nM 4.25
CHEMBL2334489 IC50 = 58270.0 nM 4.24
CHEMBL2334498 IC50 = 58900.0 nM 4.23
CHEMBL2334494 IC50 = 69320.0 nM 4.16
CHEMBL2334186 IC50 > 128000.0 nM -
CHEMBL2334185 IC50 > 128000.0 nM -
CHEMBL2334496 IC50 > 128000.0 nM -
CHEMBL2334495 IC50 > 128000.0 nM -
CHEMBL2334493 IC50 = 113600.0 nM -
CHEMBL2334492 IC50 > 128000.0 nM -
CHEMBL2334491 IC50 > 128000.0 nM -
CHEMBL2334487 IC50 > 128000.0 nM -
CHEMBL2334192 IC50 > 128000.0 nM -
CHEMBL2334191 IC50 > 128000.0 nM -
CHEMBL2334190 IC50 > 128000.0 nM -
CHEMBL2334189 IC50 > 128000.0 nM -
CHEMBL2334188 IC50 > 128000.0 nM -
CHEMBL2334187 IC50 > 128000.0 nM -
CHEMBL2334505 IC50 > 128000.0 nM -
CHEMBL2334500 IC50 > 128000.0 nM -
CHEMBL2334503 IC50 > 128000.0 nM -
CHEMBL2334193 IC50 > 128000.0 nM -