Assay Detail
Functional
CHEMBL2339882
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Agonist activity at recombinant human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins by cAMP-competition binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 9.00 |
| CHEMBL179840 | — | — | 1 | 5.06 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | - |
| CHEMBL2331642 | — | — | 1 | - |
| CHEMBL16901 | HONOKIOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL179840 | — | EC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL111 | RIMONABANT | EC50 | - | — | - | |
| CHEMBL2331642 | — | EC50 | - | — | - | |
| CHEMBL16901 | HONOKIOL | EC50 | - | — | - |