Assay Detail
Binding
CHEMBL2340177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from KOR in Hartley guinea pig membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orvinols with mixed kappa/mu opioid receptor agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.82 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2338743 | — | — | 1 | 9.40 |
| CHEMBL511142 | BUPRENORPHINE | 4.0 | 1 | 9.30 |
| CHEMBL2338754 | — | — | 1 | 8.92 |
| CHEMBL2338735 | — | — | 1 | 8.70 |
| CHEMBL2338755 | — | — | 1 | 8.33 |
| CHEMBL2338736 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2338743 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL511142 | BUPRENORPHINE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2338754 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2338735 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2338755 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL2338736 | — | Ki | = | 5.5 | nM | 8.26 |