Assay Detail
Binding
CHEMBL2340474
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Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by isothermal titration calorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.93 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333412 | — | — | 1 | 7.75 |
| CHEMBL106848 | — | — | 1 | 6.10 |
| CHEMBL2333410 | — | — | 1 | - |
| CHEMBL2333417 | — | — | 1 | - |
| CHEMBL2333416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333412 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL106848 | — | Kd | = | 790.0 | nM | 6.10 |
| CHEMBL2333410 | — | Kd | <= | 12.0 | nM | - |
| CHEMBL2333417 | — | Kd | <= | 12.0 | nM | - |
| CHEMBL2333416 | — | Kd | <= | 12.0 | nM | - |